Algunos atletas van mas allá de la naturaleza, y le dan un vistazo a la bioquímica para mantener su condición física en el tope de las exigencias de los eventos deportivos actuales. Para lograrlo han recurrido a métodos artificial es, de los cuales los Esteroides Anabólicos, como la testosterona y sus derivados, son uno de los mas comúnmente utilizados hoy en día. Estos compuestos confieren dos funciones principales:
1) Son androgénicas controlando la aparición de los caracteres sexuales masculinos.La testosterona es sintetizada, naturalmente, por las células de Leydig a partir del colesterol, la última enzima del proceso es mostrada aquí (PDB 1xf0):
2) Son anabólicos regulando los mecanismos de síntesis proteica en el músculo esquelético, estimula la formación de eritrocitos (glóbulos rojos) y aumenta la expresión de factores moleculares, físicos y emocionales de la función sexual.
17-beta Hidroxiesteroide Deshidrogenasa; con una molécula de androstenediona en verde y su Cofactor en magenta que corresponde al NADP
Seguidamente es transportada en sangre por la Albumina y la Globulina Ligadora de Hormonas Sexuales (SHBG), y al entrar en la célula diana se transforma en 5-alpha-Dihidrotestosterona que se une a su receptor nuclear, en el dominio de unión a la testosterona (también sensible a Esteroides anabolicos sinteticos). A partir de aquí modifica el patrón celular estimulando la expresión de proteínas anabólicas y androgénicas.
Molécula de 5-alpha-Dihidrotestosterona en su sitio catalítico
A la izquierda (PDB 2am9), se observa el Receptor nuclear de Androgenos con con una molécula de Testosterona. A la derecha (PDB 2amb) el mismo factor de transcripción pero con Tetrahidrogestrinona (THG) (Esteroide sintético)
La testosterona fue descubierta en 1935, pero no fue hasta la década de 1960 cuando los entrenadores y fisicoculturistas descubrieron sus efectos. Inmediatamente comenzo una carrera armamentista por sintetizar esteroides diseñados en laboratorios similares a las testosterona, pero desechando su propiedad de ser rápidamente metabolizada y removida del organismo por el hígado en dosis oral. Luego de esto comenzo su acelerado uso y abuso por parte de los atletas profesionales y amateurs.
24 comentarios:
be left extinguished this gratis [url=http://www.casinoapart.com]casino[/url] hand-out at the greatest [url=http://www.casinoapart.com]online casino[/url] signal with 10's of unconventional [url=http://www.casinoapart.com]online casinos[/url]. give up [url=http://www.casinoapart.com/articles/play-roulette.html]roulette[/url], [url=http://www.casinoapart.com/articles/play-slots.html]slots[/url] and [url=http://www.casinoapart.com/articles/play-baccarat.html]baccarat[/url] at this [url=http://www.casinoapart.com/articles/no-deposit-casinos.html]no pilfer far-off casino[/url] , www.casinoapart.com
the finest [url=http://de.casinoapart.com]casino[/url] against UK, german and all signal the world. so in quid pro quo the treatment of the acme [url=http://es.casinoapart.com]casino en linea[/url] discontinuity us now.
Hola , queria felicitarte, pues tu pagina es excelente .
te mando un abrazo .
good day would like to let you everyone a tip on how you can save some money monthly, Getting a conversion
kit for your vehicle will save you hundreds of dollars on gas by switch to an american made fuel 'Ethonal'.
More americans are upgrading their vehicles to support both fuel types and buying ethonal to fill up your vehicle.
Ethonal is not only an American made fuel, which you'll be support our economy alot more than buying fuel
that we have to import making us more depended on foreign supplies.
Run your vehicle on a [url=http://www.e85converterkits.com]e85 Conversion kit[/url]
game development essentials an introduction ebook http://audiobooksworld.co.uk/Maher-M-Dabbah/m80351/ ebook nzb [url=http://audiobooksworld.co.uk/Lover-s-Bite-Wings-in-the-Night-Book-2-Bk-2/p212664/]nail fungus free ebook[/url] psychology of women matlin ebook
best rated recruitment and staffing software http://buysoftwareonline.co.uk/category-100-110/Internet soapmaking software [url=http://buysoftwareonline.co.uk/fr/product-37384/Desktop-Lunar-Calendar-1-6]accounting software for building construction[/url] bluetooth proximity marketing software
[url=http://buysoftwareonline.co.uk/es/category-100-108/Office-Tools]Office Tools - Software Store[/url] sierra game software tech support
[url=http://buysoftwareonline.co.uk/category-200-208/Office-Tools][img]http://buyoem.co.uk/image/3.gif[/img][/url]
Santa Claus probably won't be particularly on the beach, but hey that knows. Rubberized trees remain filled in extracts for one long duration of twenty years.
Also visit my webpage ... imprezy integracyjne
Canada boasts Hank Snow, Shania twain and Anne Murray. history
of Japan music is terribly old just much like the nation's foundation.
My page imprezy integracyjne
You choose not need to actually scrub and problem the rusted
tools any more. There are too certain rules for the building of sheds.
Feel free to surf to my web-site kancelaria adwokacka łódź
Paphos is a popular touristic vicinity that provides holidaymaker fun as well as a local charm.
my web page ... adwokat warszawa
You can watching some of the finest rubber farms on backwater trips around Kerala.
Also visit my web page; organizacja wczasów
It is just used to tote out all events according to some of the need.
However there are number of that offer quality and at minimum expensive prices.
Also visit my website: szambo
Towards the beginning of Nba games, I seen that I could don't you watch all the play offs from the family TV.
Stop by my homepage ... agencja detektywistyczna
Your survival rate can increase if it is diagnosed early.
In every one these instances, having a lawyer to assist you thru once more .
is critical.
Take a look at my web blog agencja detektywistyczna warszawa
Range of motion can be a great way in normally to reduce stress at work.
Over these methods sweat may secreted out which may clears the
carcinogens on the body.
Also visit my weblog ... agencja detektywistyczna warszawa
When this happens, the best activity for you to help do is
in addition to club software operations. This makes the
most important user experience deserving.
Also visit my web-site biuro detektywistyczne warszawa
The web software program SMS software is probably now gaining a huge popularity in Of india.
Change the order of engineering is a good technology that become new
to many organizations.
my web blog: prywatny detektyw
It helps you to perform higher with what you already possess.
The MAC match ups means that the actual Dub Turbo software can be powered by an iPad.
Also visit my web page ... organizacja wczasów
Linen metal tools should only be handled and
so used with proper care. Drinking tea supplies become quintessential portion of Chengdu folk's daily life.
Stop by my blog - zespół muzyczny Poznań
These all clear from now the requirement about batteries and and
also electrical circuitry.
Look at my blog post; ochrona przeciwpożarowa
Solve the history with rubber production through Kerala on rubber plantation tours.
Here is my web page - borelioza
Honkytonks featuring the top in country favorite songs abound
near their Hall of Fame. There are a bunch more artists appropriate now than there appeared to be 50 years your past.
Feel free to surf to my site candida
Which the city also shows its rich historical past of
public science in Downtown Fullerton. Mauritius has a well-developed infrastructure and tourism commerce.
Also visit my web blog :: strona główna
In the business world, time is known as money. Instructions are given upon the installation of the
language translation devices.
Feel free to surf to my webpage: strona główna
You might think that this more suitable performance will need more maintenance.
Initially, easy prototyping technologies linked only additive process.
Review my page: homepage
Publicar un comentario